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  1. (1. 西安电子科技大学 计算机学院,陕西 西安 710071;2. 河南科技大学 电子信息工程学院,河南 洛阳 471003)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2007-10-20 发布日期:2007-10-25

Research on the construction of delay gene regulatory network

ZHANG Hong-yi1,2;ZHANG Jun-ying1

  1. (1. School of Computer, Xidian Univ., Xi′an 710071, China;2. Henan Science and Technology University, Luoyang 471003, China)
  • Received:1900-01-01 Revised:1900-01-01 Online:2007-10-20 Published:2007-10-25

摘要: 在基因序列相空间重构的基础上,利用基因序列互信息极小原则可有效确定调控基因之间的转录延时,根据延时来确定实施聚类的时刻.在此基础上,通过对调控关系的预测和对反映调控误差的决定性系数的计算获得对目标基因的调控基因组,进而获得概率基因调控网络,这样做能更有效地反映基因之间的调控关系.

关键词: 基因调控网络, 基因聚类, 相空间重构

Abstract: Based on phase space construction, the transcriptional lags between genes are estimated by the minimum mutual information principle. Then, the time course expression levels of a gene is shifted according to the estimated transcriptional lag for further clustering analysis. Finally, for a target gene, the prediction of its possible parent gene sets and the coefficient of determination (CoD) are employed to compute the probability of selecting a parent gene set from all the possible parent gene sets for the target gene. Some experiments have been performed, indicating that the feasibility and validity of constructing a gene regulatory network with the proposed method are superior to those by the conventional methods.

Key words: gene regulatory network, gene clustering, graph space reconstruction


  • TP391.4