Abstract: Based on phase space construction, the transcriptional lags between genes are estimated by the minimum mutual information principle. Then, the time course expression levels of a gene is shifted according to the estimated transcriptional lag for further clustering analysis. Finally, for a target gene, the prediction of its possible parent gene sets and the coefficient of determination (CoD) are employed to compute the probability of selecting a parent gene set from all the possible parent gene sets for the target gene. Some experiments have been performed, indicating that the feasibility and validity of constructing a gene regulatory network with the proposed method are superior to those by the conventional methods.

Key words: gene regulatory network, gene clustering, graph space reconstruction