基于真实头模型的经颅磁声电刺激感应电流密度仿真分析

doi:10.16180/j.cnki.issn1007-7820.2021.06.003

Abstract

Abstract:

The focusing characteristics of the induced current density is the key to precise neural regulation. The structure of the skull has an important influence on the induced current density distribution of TMAES. Therefore, a realistic human head model based on the CT data of the human head is established using the 3D calculating method. The finite element method is used to simulate the model during TMAES. The distribution of induced current density is obtained and subsequently evaluated. In order to further explore the relationship between the stimulus effect and the ultrasound frequency, ultrasonic waves with frequencies of 300 kHz, 400 kHz and 500 kHz are applied on the realistic human head model during TMAES. The results show that the increase of the frequency of the ultrasonic signal can increase the stimulation intensity, the stimulation length and the focus area. These results indicate that TMAES has good depth stimulation and focusing characteristics, and has the potential to noninvasively modulate neurons deep in the brain.

Key words: TMAES, realistic human head model, finite element method, magneto-acoustic coupling, induced current, focusing characteristics, ultrasound, 3D reconstruction

CLC Number:

TP391.9

LIU Yaze,ZHANG Shuai,GUO Liang,CHEN Xintong,WU Jiankang. Simulation Analysis of Induced Current Density of Transcranial Magnetic-Acoustical Electrical Stimulation Based on Realistic Human Head Model[J].Electronic Science and Technology, 2021, 34(6): 17-22.

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References 17

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参数	头皮	颅骨	大脑
密度ρ/kg·m^-3	1 060	1 220	1 050
电导率σ/S·m^-1	0.31	0.02	0.30
声速c₀/m·s^-1	1 585	4 080	1 541
平均衰减系数/dB·(cm·MHz)^-1	1.30	20.00	0.85

参数		数值
频率f/kHz	300	400	500
刺激强度J_p/mA·mm^-2	0.29	0.30	0.32
刺激长度l/mm	22.50	23.00	23.20
刺激区域横截面积S/mm²	14.50	19.60	26.40

Simulation Analysis of Induced Current Density of Transcranial Magnetic-Acoustical Electrical Stimulation Based on Realistic Human Head Model

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